children contacting with smear positive tuberculosis patients

i read the recent publication on children contacting with smear positive tuberculosis patients with great interest.[1] aminzadeh et al . concluded that the ‘strategy of six months of supervised isonicotinylhydrazine (inh) chemoprophylaxis is successful, particularly in children who are at high risk to progress to the disease, following exposure.[1] i agree with the usefulness and effectiveness of such a practice. however, i am concerned about the possible side effects of chemoprophylaxis on the children. a further cost-benefit weighting study is warranted.